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palmitoyl dhcer  (Avanti Polar)


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    Structured Review

    Avanti Polar palmitoyl dhcer
    Palmitoyl Dhcer, supplied by Avanti Polar, used in various techniques. Bioz Stars score: 90/100, based on 27 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/c16+dhcer/C16+Dihydroceramide/pm31647901-50-6-12
    Average 90 stars, based on 27 article reviews
    palmitoyl dhcer - by Bioz Stars, 2026-09
    90/100 stars

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    Related Articles

    Mass Spectrometry:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).

    In Vitro:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).

    Injection:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).

    Intra Assay:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).

    Tandem Mass Spectroscopy:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).

    Concentration Assay:

    Article Title: Monitoring the Sphingolipid de novo Synthesis by Stable-Isotope Labeling and Liquid Chromatography-Mass Spectrometry
    Article Snippet: Cer d18:0/16:0 (C16 dhCer), Cer d18:1/16:0 (C16 Cer), Cer d18:1/17:0 (C17 Cer), d18:0 Sph (dhSph) and d17:0 Sph were from Avanti Polar Lipids (Alabaster, United States).



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    A Total Chol levels in WT and CCR5 −/− OT‐II lymphoblasts (day 10, IL‐2‐expanded) as determined by a fluorometric assay ( n = 6). B–D SM (B), Cer (C) and <t>dhCer</t> (D) levels in WT and CCR5 −/− OT‐II 10‐day lymphoblasts, as determined by UPLC‐TOF MS. Values, after normalization with C17 standards and cell number in each sample, are the mean of two independent experiments ( n = 6). E RT–qPCR determination of CerS mRNA levels in naïve and IL‐2‐expanded WT and CCR5 ‐/− OT‐II 10‐day lymphoblasts ( n = 3–5). F Representative immunoblot showing CerS2 protein levels in naïve and WT and CCR5 −/− OT‐II 10‐day lymphoblasts, and densitometric quantification of blots as above ( n = 10). G ChIP analysis of the CerS2 promoter using an anti‐H3K9Ac antibody. Scheme of the CerS2 promoter showing CpG islands and primers used for amplification. Relative ChIP of the CerS2 promoter in WT and CCR5 −/− OT‐II 10‐day lymphoblasts ( n = 3). H Relative CerS2 mRNA level in CD4 T cells treated with PTx ( n = 3). I Scheme of a canonical CerS gene to illustrate the in silico strategy used to search for CerS‐specific transcription factors. J, K Venn diagrams showing the number of transcription factors with putative binding sites in the indicated CerS genes in regions 1 (J) and 2 (K). The red circle highlights the transcription factors shared by CerS2, CerS3, and CerS4 promoters, but not present in the CerS6 promoter. L Representative immunofluorescence images showing pSer142‐GATA‐1 staining (green) of OT‐II WT and CCR5 −/− lymphoblasts. The green channel (top) and the merge with nuclear DAPI staining (blue; bottom) are shown. Scale bar, 10 μm. M Quantification of nuclear staining of the cells plotted as integrated density fluorescence intensity in DAPI‐stained area ( n ≥ 50 cells/condition). N Top, basic scheme of the CerS2 promoter, indicating the putative GATA‐1 binding site (blue) and location of the primers used for amplification in ChIP assays (black arrows). Bottom, relative anti‐GATA‐1 ChIP levels in OT‐II WT and CCR5 −/− lymphoblasts ( n = 5). Data information: (E, G, H, N), Each data point is the average of triplicates in an independent experiment. (A–H, M, N), Data shown as mean ± SEM of triplicates; * P < 0.05, ** P < 0.01, *** P < 0.001, two‐tailed unpaired Student's t ‐test. Source data are available online for this figure.
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    A Total Chol levels in WT and CCR5 −/− OT‐II lymphoblasts (day 10, IL‐2‐expanded) as determined by a fluorometric assay ( n = 6). B–D SM (B), Cer (C) and <t>dhCer</t> (D) levels in WT and CCR5 −/− OT‐II 10‐day lymphoblasts, as determined by UPLC‐TOF MS. Values, after normalization with C17 standards and cell number in each sample, are the mean of two independent experiments ( n = 6). E RT–qPCR determination of CerS mRNA levels in naïve and IL‐2‐expanded WT and CCR5 ‐/− OT‐II 10‐day lymphoblasts ( n = 3–5). F Representative immunoblot showing CerS2 protein levels in naïve and WT and CCR5 −/− OT‐II 10‐day lymphoblasts, and densitometric quantification of blots as above ( n = 10). G ChIP analysis of the CerS2 promoter using an anti‐H3K9Ac antibody. Scheme of the CerS2 promoter showing CpG islands and primers used for amplification. Relative ChIP of the CerS2 promoter in WT and CCR5 −/− OT‐II 10‐day lymphoblasts ( n = 3). H Relative CerS2 mRNA level in CD4 T cells treated with PTx ( n = 3). I Scheme of a canonical CerS gene to illustrate the in silico strategy used to search for CerS‐specific transcription factors. J, K Venn diagrams showing the number of transcription factors with putative binding sites in the indicated CerS genes in regions 1 (J) and 2 (K). The red circle highlights the transcription factors shared by CerS2, CerS3, and CerS4 promoters, but not present in the CerS6 promoter. L Representative immunofluorescence images showing pSer142‐GATA‐1 staining (green) of OT‐II WT and CCR5 −/− lymphoblasts. The green channel (top) and the merge with nuclear DAPI staining (blue; bottom) are shown. Scale bar, 10 μm. M Quantification of nuclear staining of the cells plotted as integrated density fluorescence intensity in DAPI‐stained area ( n ≥ 50 cells/condition). N Top, basic scheme of the CerS2 promoter, indicating the putative GATA‐1 binding site (blue) and location of the primers used for amplification in ChIP assays (black arrows). Bottom, relative anti‐GATA‐1 ChIP levels in OT‐II WT and CCR5 −/− lymphoblasts ( n = 5). Data information: (E, G, H, N), Each data point is the average of triplicates in an independent experiment. (A–H, M, N), Data shown as mean ± SEM of triplicates; * P < 0.05, ** P < 0.01, *** P < 0.001, two‐tailed unpaired Student's t ‐test. Source data are available online for this figure.
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    Image Search Results


    A Total Chol levels in WT and CCR5 −/− OT‐II lymphoblasts (day 10, IL‐2‐expanded) as determined by a fluorometric assay ( n = 6). B–D SM (B), Cer (C) and dhCer (D) levels in WT and CCR5 −/− OT‐II 10‐day lymphoblasts, as determined by UPLC‐TOF MS. Values, after normalization with C17 standards and cell number in each sample, are the mean of two independent experiments ( n = 6). E RT–qPCR determination of CerS mRNA levels in naïve and IL‐2‐expanded WT and CCR5 ‐/− OT‐II 10‐day lymphoblasts ( n = 3–5). F Representative immunoblot showing CerS2 protein levels in naïve and WT and CCR5 −/− OT‐II 10‐day lymphoblasts, and densitometric quantification of blots as above ( n = 10). G ChIP analysis of the CerS2 promoter using an anti‐H3K9Ac antibody. Scheme of the CerS2 promoter showing CpG islands and primers used for amplification. Relative ChIP of the CerS2 promoter in WT and CCR5 −/− OT‐II 10‐day lymphoblasts ( n = 3). H Relative CerS2 mRNA level in CD4 T cells treated with PTx ( n = 3). I Scheme of a canonical CerS gene to illustrate the in silico strategy used to search for CerS‐specific transcription factors. J, K Venn diagrams showing the number of transcription factors with putative binding sites in the indicated CerS genes in regions 1 (J) and 2 (K). The red circle highlights the transcription factors shared by CerS2, CerS3, and CerS4 promoters, but not present in the CerS6 promoter. L Representative immunofluorescence images showing pSer142‐GATA‐1 staining (green) of OT‐II WT and CCR5 −/− lymphoblasts. The green channel (top) and the merge with nuclear DAPI staining (blue; bottom) are shown. Scale bar, 10 μm. M Quantification of nuclear staining of the cells plotted as integrated density fluorescence intensity in DAPI‐stained area ( n ≥ 50 cells/condition). N Top, basic scheme of the CerS2 promoter, indicating the putative GATA‐1 binding site (blue) and location of the primers used for amplification in ChIP assays (black arrows). Bottom, relative anti‐GATA‐1 ChIP levels in OT‐II WT and CCR5 −/− lymphoblasts ( n = 5). Data information: (E, G, H, N), Each data point is the average of triplicates in an independent experiment. (A–H, M, N), Data shown as mean ± SEM of triplicates; * P < 0.05, ** P < 0.01, *** P < 0.001, two‐tailed unpaired Student's t ‐test. Source data are available online for this figure.

    Journal: The EMBO Journal

    Article Title: CCR 5 deficiency impairs CD 4 + T‐cell memory responses and antigenic sensitivity through increased ceramide synthesis

    doi: 10.15252/embj.2020104749

    Figure Lengend Snippet: A Total Chol levels in WT and CCR5 −/− OT‐II lymphoblasts (day 10, IL‐2‐expanded) as determined by a fluorometric assay ( n = 6). B–D SM (B), Cer (C) and dhCer (D) levels in WT and CCR5 −/− OT‐II 10‐day lymphoblasts, as determined by UPLC‐TOF MS. Values, after normalization with C17 standards and cell number in each sample, are the mean of two independent experiments ( n = 6). E RT–qPCR determination of CerS mRNA levels in naïve and IL‐2‐expanded WT and CCR5 ‐/− OT‐II 10‐day lymphoblasts ( n = 3–5). F Representative immunoblot showing CerS2 protein levels in naïve and WT and CCR5 −/− OT‐II 10‐day lymphoblasts, and densitometric quantification of blots as above ( n = 10). G ChIP analysis of the CerS2 promoter using an anti‐H3K9Ac antibody. Scheme of the CerS2 promoter showing CpG islands and primers used for amplification. Relative ChIP of the CerS2 promoter in WT and CCR5 −/− OT‐II 10‐day lymphoblasts ( n = 3). H Relative CerS2 mRNA level in CD4 T cells treated with PTx ( n = 3). I Scheme of a canonical CerS gene to illustrate the in silico strategy used to search for CerS‐specific transcription factors. J, K Venn diagrams showing the number of transcription factors with putative binding sites in the indicated CerS genes in regions 1 (J) and 2 (K). The red circle highlights the transcription factors shared by CerS2, CerS3, and CerS4 promoters, but not present in the CerS6 promoter. L Representative immunofluorescence images showing pSer142‐GATA‐1 staining (green) of OT‐II WT and CCR5 −/− lymphoblasts. The green channel (top) and the merge with nuclear DAPI staining (blue; bottom) are shown. Scale bar, 10 μm. M Quantification of nuclear staining of the cells plotted as integrated density fluorescence intensity in DAPI‐stained area ( n ≥ 50 cells/condition). N Top, basic scheme of the CerS2 promoter, indicating the putative GATA‐1 binding site (blue) and location of the primers used for amplification in ChIP assays (black arrows). Bottom, relative anti‐GATA‐1 ChIP levels in OT‐II WT and CCR5 −/− lymphoblasts ( n = 5). Data information: (E, G, H, N), Each data point is the average of triplicates in an independent experiment. (A–H, M, N), Data shown as mean ± SEM of triplicates; * P < 0.05, ** P < 0.01, *** P < 0.001, two‐tailed unpaired Student's t ‐test. Source data are available online for this figure.

    Article Snippet: Soybean phosphatidylcholine Chol, egg SM, C12 Cer (d18:1/12:0), C16 Cer (d18:1/16:0), C18 Cer (d18:1/18:0), C24 Cer (d18:1/24:0), C24:1 Cer (d18:1/24:1(15Z)), C16 dhCer (d18:0/16:0), C18 dhCer (d18:0/18:0), C24 dhCer (d18:0/24:0), C24:1 dhCer (d18:0/24:1(15Z)), C12:0 SM (d18:1/12:0), C16:0 SM (d18:1/16:0), C18:0 SM (d18:1/18:0), C24:0 SM, C24:1 SM, and the Cer mix from bovine spinal cord were from Avanti Polar Lipids.

    Techniques: Quantitative RT-PCR, Western Blot, Amplification, In Silico, Binding Assay, Immunofluorescence, Staining, Fluorescence, Two Tailed Test

    Analysis of TCR nanoclustering in lymphoblasts from healthy WT and ccr5 Δ32 homozygous donors by EM. Top, representative small field image showing gold particle distribution in cell surface replicas of anti‐CD3ε‐labeled cells; bottom, quantification (mean ± SEM) of gold particles in clusters of the indicated size in the WT (gray bars; n = 5 cells, 17,689 particles) and Δ32/Δ32 cells (light red; n = 4 cells, 16,938 particles). Insets show the distribution between clusters of one, two, three, four, or more than four particles, and statistical analysis. Normalized SM, Cer, and dhCer levels in lymphoblasts obtained as in (A). A representative experiment is shown ( n = 3 donors/genotype; n = 2 independent experiments). Relative CerS2 mRNA levels in day 8 WT and ccr5 Δ32 lymphoblasts. Each data point is the average of a technical triplicate from three donors in two independent experiments ( n = 6). Data information: Data are shown as mean ± SEM (B, C). * P < 0.05, ** P < 0.01, two‐tailed unpaired Student's t ‐test. Scale bar, 50 nm.

    Journal: The EMBO Journal

    Article Title: CCR 5 deficiency impairs CD 4 + T‐cell memory responses and antigenic sensitivity through increased ceramide synthesis

    doi: 10.15252/embj.2020104749

    Figure Lengend Snippet: Analysis of TCR nanoclustering in lymphoblasts from healthy WT and ccr5 Δ32 homozygous donors by EM. Top, representative small field image showing gold particle distribution in cell surface replicas of anti‐CD3ε‐labeled cells; bottom, quantification (mean ± SEM) of gold particles in clusters of the indicated size in the WT (gray bars; n = 5 cells, 17,689 particles) and Δ32/Δ32 cells (light red; n = 4 cells, 16,938 particles). Insets show the distribution between clusters of one, two, three, four, or more than four particles, and statistical analysis. Normalized SM, Cer, and dhCer levels in lymphoblasts obtained as in (A). A representative experiment is shown ( n = 3 donors/genotype; n = 2 independent experiments). Relative CerS2 mRNA levels in day 8 WT and ccr5 Δ32 lymphoblasts. Each data point is the average of a technical triplicate from three donors in two independent experiments ( n = 6). Data information: Data are shown as mean ± SEM (B, C). * P < 0.05, ** P < 0.01, two‐tailed unpaired Student's t ‐test. Scale bar, 50 nm.

    Article Snippet: Soybean phosphatidylcholine Chol, egg SM, C12 Cer (d18:1/12:0), C16 Cer (d18:1/16:0), C18 Cer (d18:1/18:0), C24 Cer (d18:1/24:0), C24:1 Cer (d18:1/24:1(15Z)), C16 dhCer (d18:0/16:0), C18 dhCer (d18:0/18:0), C24 dhCer (d18:0/24:0), C24:1 dhCer (d18:0/24:1(15Z)), C12:0 SM (d18:1/12:0), C16:0 SM (d18:1/16:0), C18:0 SM (d18:1/18:0), C24:0 SM, C24:1 SM, and the Cer mix from bovine spinal cord were from Avanti Polar Lipids.

    Techniques: Labeling, Two Tailed Test